mRNA Happy Birthday Greeting Card

Transcriptional control is the regulation of gene expression through a combination of transcription factors, RNA polymerase, and specific DNA elements known as promoters, enhancers, silencers, and locus-control elements. This process results in the production of pre-mRNA, which undergoes processing to become a functional mRNA. This includes splicing out introns, adding a 5' cap and a 3' poly(A) tail, and potentially editing the mRNA sequence. The final mRNA molecule in eukaryotes has three parts: a 5' untranslated region (5' UTR), a coding region with triplet codons encoding amino acids, and a 3' untranslated region (3' UTR).

The rapid authorization of two mRNA-based COVID-19 vaccines just 11 months after the discovery of the virus highlights the potential of mRNA technology. So far, most mRNA applications have focused on vaccines for infectious diseases and cancer, which can be effective with low doses and local delivery due to the innate immune-stimulating properties of some mRNA. There has also been progress in mRNA-based protein or cell immunotherapies, which pose different manufacturing and formulation challenges as they require high protein expression in target cells and tissues and may need to be administered repeatedly. Over the past few years, there has been clinical progress in COVID-19 vaccines, Omicron boosters, and vaccines for seasonal flu, Epstein-Barr virus, HIV, and cancer.

Our mRNA Happy birthday made of genetic codons! A codon is a sequence of three nucleotides (a trinucleotide) found in DNA or RNA that functions as a unit of genetic information. It can either specify an amino acid for protein synthesis or signal the end of protein synthesis (stop signals). There are a total of 64 different codons, 61 of which specify amino acids and the remaining 3 function as stop signals. The diversity and complexity of genetic codons are what make every living organism unique. On your special day, let's celebrate the amazing genetic codons that make you, you!

• Material: 14.77 oz/yd² (350 g/m²) paperboard
• Size: 5″ × 7″ (127 × 178 mm)
• Vibrant colors
• Comes with a complimentary envelope